Vitamins that may be helpful
Antioxidants may protect the skin from
sunburn due to free radical–producing
ultraviolet rays.3 Combinations of 1,000 to 2,000 IU per day of vitamin E and 2,000 to 3,000 mg per day of vitamin C, but neither given alone, have a significant
protective effect against ultraviolet rays, according to double-blind studies.4
5 6
Oral synthetic beta-carotene alone was not
found to provide effective protection when given in amounts of 15 mg per day or for only a few
weeks’ time in larger amounts of 60 to 90 mg per day, but it has been effective either
in very large (180 mg per day) amounts or in smaller amounts (30 mg per day) in combination
with topical sunscreen.7 8 9 10 11
Natural sources of beta-carotene or other
carotenoids have been more consistently shown
to protect against sunburn. One controlled study found that taking a supplement of natural
carotenoids (almost all of which was beta-carotene) in daily amounts of 30 mg, 60 mg, and 90
mg gave progressively more protection against ultraviolet rays.12 In another
controlled study, either 24 mg per day of natural beta-carotene or 24 mg per day of a
carotenoid combination of equal amounts beta-carotene, lutein, and lycopene helped protect skin from ultraviolet
rays.13 A preliminary study compared synthetic lycopene (10.1 mg per day), a
natural tomato extract containing 9.8 mg of lycopene per day plus additional amounts of other
carotenoids, and a solubilized tomato drink (designed to increase lycopene absorption)
containing 8.2 mg of lycopene plus additional amounts of other carotenoids. After 12 weeks,
only the two tomato-based products were shown to give significant protection against burning
by ultraviolet light.14
Still other trials have tested combinations of several antioxidants. One preliminary study found that a daily
combination of beta-carotene (6 mg), lycopene
(6 mg), vitamin E (15 IU), and selenium for seven weeks protected against ultraviolet
light.15 However, a double-blind trial of a combination of smaller amounts of
several carotenoids, vitamins C and E,
selenium, and proanthocyanidins did not find
significant UV protection compared with placebo.16 Similarly, in a controlled
trial, a combination of selenium, copper, and
vitamins was found to be ineffective.17
It should be noted that while oral protection from sunburn has been demonstrated with
several types of antioxidants, the degree of
protection (typically less than an SPF of 2) is much less than that provided by currently
available topical sunscreens. On the other hand, these modest effects will provide some added
protection to skin areas where sunscreen is also used and will give a small amount of
protection to sun-exposed areas where sunscreen is not applied. However, oral protection from
sunburn is not instantaneous; maximum effects are not reached until these antioxidants have
been used for about eight to ten weeks.18 19
Proanthocyanidins (OPCs) are a group of
flavonoids found in pine bark, grape seed, and other plant sources. In a preliminary
trial, volunteers were supplemented with Pycnogenol, an extract of French maritime pine bark
rich in OPCs, in the amount of 1.1 mg per 2.2 pounds of body weight per day for the first four
weeks, and 1.66 mg per 2.2 pounds of body weight per day for the next four weeks.20
Compared with ultraviolet sensitivity before supplementation, the lower amount of Pycnogenol
was found to significantly increase the amount of ultraviolet rays necessary to cause sunburn,
and the higher amount was significantly more effective than the lower amount.
Antioxidants have also been studied as
topical agents for protection against sunburn. Animal studies have found sunscreen-like
effects from topical application of a vitamin
C and vitamin E combination, and a
controlled human study reported ultraviolet protection from the use of a lotion containing
0.02% to 0.05% of the selenium-containing amino acid known as
selenomethionine.21 22 The topical use of the hormone melatonin has been
shown to protect human skin against ultraviolet rays in double-blind research.23
24 A double-blind human trial tested topical vitamins C and E and melatonin, alone and in combinations, and found the
highest degrees of protection from combination formulations containing 2% vitamin E, 5%
vitamin C, and 1% to 2.5% melatonin.25 Other studies in which topical antioxidants
were applied after ultraviolet exposure have found no benefits.26 27
Are there any side effects or interactions?
Refer to the individual supplement for information about any side effects or interactions.
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products increases lycopene, phytofluene, and phytoene levels in human serum and protects
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2. Stahl W, Heinrich U, Wiseman S, et al. Dietary tomato paste protects
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20. Saliou C, Rimbach G, Moini H, et al. Solar ultraviolet-induced
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22. Burke KE, Burford RG, Combs GF Jr, et al. The effect of topical
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25. Dreher F, Gabard B, Schwindt DA, Maibach HI. Topical melatonin in
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