Also indexed as: Pyruvic Acid
Pyruvate (the buffered form of pyruvic acid) is a product created in the body during the
metabolism of carbohydrates and protein.
Where is it found?
Pyruvate is formed in the body as a byproduct of the normal metabolism of carbohydrates and
protein and is present in several foods, including red apples,
cheese, dark beer, and red wine. Dietary supplements of pyruvate are also available.
Pyruvate has been used in
connection with the following conditions (refer to the individual
health concern for complete information):
Who is likely to be deficient?
Because it is not an essential nutrient, pyruvate is not associated with a deficiency
How much is usually taken?
Most human research with pyruvate and weight
loss has used at least 30 grams per day. However, such large amounts may not be necessary.
In a six-week double-blind trial, as little as 6 grams per day of pyruvate in combination with
exercise, led to greater weight loss and loss of body fat, compared with a placebo plus
Are there any side effects or interactions?
High intakes of pyruvate can trigger
gastrointestinal upset, such as gas, bloating, and diarrhea. One preliminary study in exercising women
found 10 grams per day of pyruvate reduced blood levels of HDL (the “good”
cholesterol) after one month.2
At the time of writing, there were no well-known drug interactions
1. Kalman D, Colker CM, Wilets I, et al. The effects of pyruvate
supplementation on body composition in overweight individuals. Nutrition
2. Koh P, Kreider R, Ferreira M, et al. Effects of pyruvate
supplementation during training on hematologic and metabolic profiles. Med Sci Sports
Exerc 1998;30:S155 [abstract].