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Also indexed as: 2-Dimethylaminoethanol, Dimethylaminoethanol


DMAE (2-dimethylaminoethanol) is a chemical produced in the brain.

Where is it found?

DMAE is found as a supplement, although it is not widely available.

DMAE has been used in connection with the following conditions (refer to the individual health concern for complete information):

Science Ratings Health Concerns

Alzheimer’s disease

Tardive dyskinesia

3Stars Reliable and relatively consistent scientific data showing a substantial health benefit.
2Stars Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.
1Star For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support and/or minimal health benefit.

Who is likely to be deficient?

No deficiencies of DMAE are reported or believed to occur.

How much is usually taken?

DMAE supplementation is not recommended at this time.

Are there any side effects or interactions?

Clinical studies of DMAE have used up to 1,600 mg per day with no reports of side effects.1 For this reason, DMAE is believed to be relatively nontoxic. However, one study using higher intakes for Alzheimer’s disease patients did report symptoms of drowsiness and confusion with the use of DMAE.2 A possible side effect of lucid dreaming (in which the dreamer is conscious and in control of a dream) is suggested with DMAE use.3 Depression and hypomania (moderate symptoms of mania) have been reported as side effects of DMAE.4

At the time of writing, there were no well-known drug interactions with DMAE.


1. Casey DE, Denney D. Dimethylaminoethanol in tardive dyskinesia. N Engl J Med 1974;291:797.

2. Fisman M, Mersky H, Helmes E. Double-blind trial of 2-dimethylaminoethanol in Alzheimer’s disease. Am J Psychiatry 1981;138:970–2.

3. Sergio W. Use of DMAE (2-dimethylaminoethanol) in the induction of lucid dreams. Med Hypotheses 1988;26:255–7.

4. Casey DE. Mood alterations during deanol therapy. Psychopharmacology 1979;62:187–91.

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