Borage oil is derived from the seeds of the borage (Borago officinalis) plant, a
large plant with blue, star-shaped flowers found throughout Europe and North Africa and
naturalized to North America.1
Where is it found?
Borage oil is found primarily in supplements. Its presumed active ingredient, GLA, can also
be found in black currant seed oil and evening
primrose oil supplements. However, it is not known whether the effects of these three oils
in the body, are the same.
Borage oil has been used
in connection with the following conditions (refer to the individual
health concern for complete information):
Who is likely to be deficient?
Many people in Western societies may be at least partially GLA-deficient as a result of
aging, glucose intolerance, dietary fat
intake, and other problems, though the exact incidence of deficiency remains unknown. People
with deficiencies benefit from supplemental GLA intake from borage oil, black currant seed
oil, or evening primrose oil.
Those with premenstrual
syndrome,2
diabetes,3 scleroderma,4 Sjogren’s syndrome,5 tardive dyskinesia,6 eczema,7 and other skin
conditions8 may have a metabolic block that interferes with the body’s
ability to make GLA. However, most clinical trials supplementing GLA for these conditions has
used evening primrose oil, and not borage oil.
How much is usually taken?
For the treatment of rheumatoid arthritis,
the amounts of GLA from borage used in successful double-blind trials were 1.4–2.8 grams
daily for at least two months.9 10 Although 360 mg of GLA daily from
borage oil has been used to treat people with
eczema, controlled research has not supported its use for this condition.11
Topically, 0.5 ml of borage oil may be applied to areas of seborrhea daily for two weeks, and then three times a
week until the condition is stable.12
Are there any side effects or interactions?
Borageseeds contain small amounts of liver toxins called pyrrolizidine alkaloids
(PA). However, testing has not demonstrated the presence of the alkaloid in the seed
oil.13 Most commercially available borage seed oil is, therefore, likely to be
PA-free and presents no risk of PA toxicity. Minor side effects from borage oil use can
include bloating, nausea, indigestion, and
headache.14
At the time of writing, there were no well-known drug interactions
with borage oil.
References:1. Wren RC. Potter’s New Cyclopedia of Botanical Drugs and
Preparations. Essex, England: C.W. Daniel and Co., 1988, 41.
2. Horrobin DF, Manku M, Brush M, et al. Abnormalities in plasma
essential fatty acid levels in women with pre-menstrual syndrome and with non-malignant breast
disease. J Nutr Med 1991;2:259–64.
3. Keen H, Payan J, Allawi J, et al. Treatment of diabetic neuropathy
with gamma-linolenic acid. Diabetes Care 1993;16:8–15.
4. Horrobin DF. Essential fatty acid metabolism in diseases of connective
tissue with special reference to scleroderma and to Sjogren’s syndrome. Med
Hypotheses 1984;14:233–47.
5. Horrobin DF, Campbell A. Sjogren’s syndrome and the sicca
syndrome: the role of prostaglandin E1 deficiency. Treatment with essential fatty acids and
vitamin C. Med Hypotheses 1980;6:225–32.
6. Vaddadi KS, Gilleard CJ. Essential fatty acids, tardive dyskinesia,
and schizophrenia. In Omega-6 Essential Fatty Acids: Pathophysiology and Roles in Clinical
Medicine. Horrobin DF (ed). New York: Alan R Liss, 1990, 333–43.
7. Manku MS, Horrobin, DF, Morse NL, et al. Essential fatty acids in the
plasma phospholipids of patients with atopic eczema. Br J Dermatol 1984;110:643.
8. Horrobin DF. Essential fatty acids in clinical dermatology. J Am
Acad Dermatol 1989;20:1045–53.
9. Leventhal LJ, Boyce EG, Zurier RB. Treatment of rheumatoid arthritis
with gammalinolenic acid. Ann Intern Med 1993;119:867–73.
10. Zurier RB, Rossetti RG, Jacobson EW, et al. Gamma-linolenic acid
treatment of rheumatoid arthritis. A randomized, placebo-controlled trial. Arthritis
Rheum 1996;39:1808–17.
11. Landi G. Oral administration of borage oil in atopic dermatitis.
J Appl Cosmetology 1993;11:115–20.
12. Tolleson A, Frithz A. Borage oil, an effective new treatment for
infantile seborrhoeic dermatitis. Br J Dermatol 1993;25:95.
13. Parvais O, Vander Stricht B, Vanhaelen-Fastré R,Vanhaelen M. TLC
detection of pyrrolizidine alkaloids in oil extracted from the seeds of Borago officinalis.
J Planar Chromatography 1994;7:80–2.
14. Awang DVC. Borage. Can Pharm J 1990;123:121–3.