Common names: Gurmarbooti, Gurmar
Botanical name: Gymnema sylvestre
Parts used and where grown
Gymnema sylvestre is a woody climbing plant that grows in the tropical forests of
central and southern India. The leaves are used in herbal medicine preparations. G.
sylvestre is known as "periploca of the woods" in English and meshasringi
(meaning “ram’s horn”) in Sanskrit. The leaves, when chewed, interfere with
the ability to taste sweetness, which explains the Hindi name
gurmar—“destroyer of sugar.”
Gymnema has been used in
connection with the following condition (refer to the individual
health concern for complete information):
Historical or traditional use (may
or may not be supported by scientific studies)
Gymnema has been used in India for the treatment of type 1 and type 2 diabetes for over 2,000 years. The leaves were
also used for stomach ailments, constipation,
water retention, and liver disease.
The hypoglycemic (blood sugar-lowering) action of gymnema leaves was first documented in
the late 1920s.1 This action is attributed to members of a family of substances
called gymnemic acids.2 3 Gymnema leaves raise insulin levels, according to research in healthy
volunteers.4 Based on animal studies, this may be due to regeneration of the cells
in the pancreas that secrete insulin,5 6 or by increasing the flow of
insulin from these cells.7 Other animal research shows that gymnema can also reduce
glucose absorption from the intestine,8 improve uptake of glucose into cells, and
prevent adrenal hormones from stimulating the liver to produce glucose, thereby reducing blood
sugar levels.9 10
Other animal studies have shown that extracts of gymnema leaves can lower serum cholesterol and triglycerides and prevent weight gain,11
12 13 14 but these effects have not been tested in humans.
When placed directly on the tongue, gurmarin, another constituent of the leaves, and gymnemic
acid have been shown to block the ability in humans to taste sweets.15
How much is usually taken?
Clinical trials with diabetics in India have used 400 mg per day of a water-soluble acidic
fraction of the gymnema leaves. The gymnemic acid content of this extract is not clear. A
recent preliminary trial in the United States reported promising results in a group of type 1
and type 2 diabetics who took 800 mg per day of an extract standardized for 25% gymnemic
acids.17 Traditionally, 2 to 4 grams per day of the leaf powder is used.
Are there any side effects or interactions?
Used at the amounts suggested, gymnema is generally safe and devoid of side effects. The
safety of gymnema during pregnancy and
breast-feeding has not yet been determined. People with diabetes should only use gymnema to
lower blood sugar under the clinical supervision of a healthcare professional. Gymnema cannot
be used in place of insulin to control blood
sugar by people with either type 1 or type 2 diabetes.
Are there any drug
Certain medicines may interact with gymnema. Refer to drug interactions for a list of those medicines.
1. Mhasker KS, Caius JF. A study of Indian medicinal plants. II.
Gymnema sylvestre R.Br. Indian J Med Res Memoirs 1930;16:2–75.
2. Sugihara Y, Nojima H, Matsuda H, et al. Antihyperglycemic effects of
gymnemic acid IV, a compound derived from Gymnema sylvestre leaves in
streptozotocin-diabetic mice. J Asian Nat Prod Res 2000;2:321–7.
3. Murakami N, Murakami T, Kadoya M, et al. New hypoglycemic constituents
in "gymnemic acid" from Gymnema sylvestre. Chem Pharm Bull (Tokyo)
4. Shanmugasundaram KR, Panneerselvam C, Sumudram P, Shanmugasundaram
ERB. Insulinotropic activity of G. sylvestre, R.Br. and Indian medicinal herb used in
controlling diabetes mellitus. Pharmacol Res Commun 1981;13:475–86.
5. Shanmugasundaram ER, Gopinath KL, Radha Shanmugasundaram K, Rajendran
VM. Possible regeneration of the islets of Langerhans in streptozotocin diabetic rats given
Gymnema sylvestre leaf extracts. J Ethnopharmacol 1990;30:265–79.
6. Prakash AO, Mather S, Mather R. Effect of feeding Gymnema
sylvestre leaves on blood glucose in beryllium nitrate treated rats. J
7. Persaud SJ, Al-Majed H, Raman A, Jones PM. Gymnema sylvestre
stimulates insulin release in vitro by increased membrane permeability. J Endocrinol
8. Shimizu K, Iino A, Nakajima J, et al. Suppression of glucose
absorption by some fractions extracted from Gymnema sylvestre leaves. J Vet Med
9. [No authors listed]. Gymnema sylvestre. Alt Med Rev
10. Gholap S, Kar A. Effects of Inula racemosa root and Gymnema
sylvestre leaf extracts in the regulation of corticosteroid induced diabetes mellitus:
involvement of thyroid hormones. Pharmazie 2003;58:413–5.
11. Bishayee A, Chatterjee M. Hypolipidemic and antiatherosclerotic
effects of oral Gymnema sylvestre R.Br. leaf extract in albino rats fed on a high fat
diet. Phytother Res 1994;8:118–20.
12. Shigematsu N, Asano R, Shimosaka M, Okazaki M. Effect of
administration with the extract of Gymnema sylvestre R. Br leaves on lipid metabolism
in rats. Biol Pharm Bull 2001;24:713–7.
13. Shigematsu N, Asano R, Shimosaka M, Okazaki M. Effect of long
term-administration with Gymnema sylvestre R. BR on plasma and liver lipid in rats.
Biol Pharm Bull 2001;24:643–9.
14. Nakamura Y, Tsumura Y, Tonogai Y, Shibata T. Fecal steroid excretion
is increased in rats by oral administration of gymnemic acids contained in Gymnema
sylvestre leaves. J Nutr 1999;129:1214–22.
15. Min BC, Sakamoto K. Influence of sweet suppressing agent on gustatory
brain evoked potentials generated by taste stimuli. Appl Human Sci
16. Gent JF, Hettinger TP, Frank ME, Marks LE. Taste confusions following
gymnemic acid rinse. Chem Senses 1999;24:393–403.
17. Joffe DJ, Freed SH. Effect of extended release gymnema sylvestre leaf
extract (Beta Fast GXR) alone or in combination with oral hypoglycemics or insulin regimens
for type 1 and type 2 diabetes. Diabetes In Control Newsletter 2001;76:no page