Also indexed as: Normodyne, Trandate
Summary of
Interactions with Vitamins, Herbs, and Foods
In some cases, an herb or supplement may appear in more than one category, which may seem
contradictory. For clarification, read the full article for details about the summarized
interactions.
 May Be Beneficial: Supportive
interaction—Taking these supplements may support or otherwise help your medication
work better. |
Food
|
Avoid: Adverse interaction—Avoid these supplements when taking this
medication because taking them together may cause undesirable or dangerous results. |
High-potassium foods*
Pleurisy root*
Potassium
|
| Depletion or interference |
None known
|
| Side effect reduction/prevention |
None known
|
| Reduced drug
absorption/bioavailability |
None known
|
An asterisk (*) next to an item in the summary indicates that the
interaction is supported only by weak, fragmentary, and/or contradictory scientific
evidence.
Interaction with Dietary Supplements
Potassium
Three kidney transplant patients developed hyperkalemia (high blood potassium levels), a
potentially dangerous condition, following intravenous administration of
labetalol.1 Additional research is needed to determine whether taking oral
labetalol together with potassium supplements might also lead to elevated blood levels of
potassium. However, some other beta-blockers (called “nonselective” beta-blockers)
are known to decrease the uptake of potassium from the blood into the cells,2
leading to hyperkalemia.3 People taking beta-blockers should therefore avoid taking
potassium supplements, or eating large quantities of fruit (e.g., bananas), unless directed to do so by their
doctor.
Interactions with Herbs
Pleurisy
root
As pleurisy root and other plants in the Aesclepius genus contain cardiac glycosides,
it is best to avoid use of pleurisy root with heart medications such as
beta-blockers.4
Interaction with Food and Other Compounds
Food
Taking labetalol with food greatly increases the absorption of the drug.5
Therefore, labetalol should be taken with a meal.
References:1. Arthur S, Greenberg A. Hyperkalemia associated with intravenous
labetalol therapy for acute hypertension in renal transplant recipients. Clin Nephrol
1990;33:269–71.
2. Rosa RM, Silva P, Young JB, et al. Adrenergic modulation of extrarenal
potassium disposal. N Engl J Med 1980;302:431–4.
3. Lundborg P. The effect of adrenergic blockade on potassium
concentrations in different conditions. Acta Med Scand Suppl 1983;672:121–6
[review].
4. Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide
for Health-Care Professionals. London: Pharmaceutical Press, 1996, 213–4.
5. Daneshmend TK, Roberts CJ. the influence of food on the oral and
intravenous pharmacokinetics of a high clearance drug: a study with labetalol. Br J Clin
Pharmacol 1982;14:73–8.