Also indexed as: Banophen, Benadryl, Benylin, Diphedryl, Simply
Sleep
Diphenhydramine is an antihistamine used to relieve allergic rhinitis (seasonal allergy) symptoms
including sneezing, runny nose, itching, and watery eyes and to relieve itching and swelling
associated with uncomplicated allergic skin reactions. It is also used as a short-term sleep aid, to control coughs due to colds or
allergy, and to prevent/treat motion
sickness. Diphenhydramine is available in nonprescription products alone and in
combination with other nonprescription drugs, to treat symptoms of allergy, colds, and upper
respiratory infections.
Summary of
Interactions with Vitamins, Herbs, and Foods
In some cases, an herb or supplement may appear in more than one category, which may seem
contradictory. For clarification, read the full article for details about the summarized
interactions.
Avoid: Adverse interaction—Avoid these supplements when taking this
medication because taking them together may cause undesirable or dangerous results. |
Henbane*
|
| Depletion or interference |
None known
|
| Side effect reduction/prevention |
None known
|
| Supportive interaction |
None known
|
| Reduced drug
absorption/bioavailability |
None known
|
An asterisk (*) next to an item in the summary indicates that the
interaction is supported only by weak, fragmentary, and/or contradictory scientific
evidence.
Interactions with Herbs
Henbane (Hyoscyamus niger)
Antihistamines, including diphenhydramine, can cause “anticholinergic” side
effects such as dryness of mouth and heart palpitations. Henbane also has anticholinergic
activity and side effects. Therefore, use with diphenhydramine could increase the risk of
anticholinergic side effects,1 though apparently no interactions have yet been
reported with diphenhydramine and henbane. Henbane should not be taken except by prescription
from a physician trained in its use, as it is extremely toxic.
Interactions with Foods and Other Compounds
Alcohol
Diphenhydramine causes drowsiness.2 Alcohol may intensify this effect and increase
the risk of accidental injury.3 To prevent problems, people taking diphenhydramine
or diphenhydramine-containing products should avoid alcohol.
References:1. Blumenthal M, ed. The Complete German Commission E
Monographs. Austin, TX: American Botanical Council, 1998, 146.
2. Threlkeld DS, ed. Respiratory Drugs, Antihistamines. In Facts and
Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, May 1998,
191a–1b.
3. Threlkeld DS, ed. Respiratory Drugs, Antihistamines. In Facts and
Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, May 1998,
191a–1b.