Interactions with Vitamins, Herbs, and Foods
In some cases, an herb or supplement may appear in more than one category, which may seem
contradictory. For clarification, read the full article for details about the summarized
Avoid: Adverse interaction—Avoid these supplements when taking this
medication because taking them together may cause undesirable or dangerous results.
Check: Other—Before taking any of these supplements or eating any of
these foods with your medication, read this article in full for details.
|Depletion or interference
|Side effect reduction/prevention
An asterisk (*) next to an item in the summary indicates that the
interaction is supported only by weak, fragmentary, and/or contradictory scientific
Interactions with Dietary Supplements
Amlodipine has been shown to raise blood levels of DHEA-sulfate in insulin-resistant, obese
men with high blood pressure.1
Interactions with Herbs
As pleurisy root and other plants in the Aesclepius genus contain cardiac glycosides,
it is best to avoid use of pleurisy root with heart medications such as calcium channel
Interactions with Foods and Other Compounds
Ingestion of grapefruit juice has been shown to increase the absorption of felodipine (a drug similar in structure and action to
that of amlodipine) and to increase the adverse effects of the medication in patients with
hypertension. Until more is known, it seems that grapefruit juice should not be ingested by
people taking amlodipine or similar drugs.3 The same effects might be seen from
eating grapefruit as from drinking its juice.
Amlodipine may be taken with or without food.4
1. Beer NA, Jakubowicz DJ, Beer RM, Nestler JE. The calcium channel
blocker amlodipine raises serum dehydroepiandrosterone sulfate and androstenedione, but lowers
serum cortisol, in insulin-resistant obese and hypertensive men. J Clin Endocrinol
2. Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide
for Health-Care Professionals. London: Pharmaceutical Press, 1996, 213–4.
3. Bailey DG, Arnold MO, Strong HA, Munoz C, Spence JD, et al. Effect of
grapefruit juice and naringin on nisoldipine pharmacokinetics. Clin Pharmacol Ther
4. Faulkner JK, Hayden ML, Chasseaud LF, Taylor T. Absorption of
amlodipine unaffected by food. Solid dose equivalent to solution dose.