Indapamide is a thiazide-like diuretic used, either alone or in combination with other
drugs, to treat high blood pressure and to
prevent salt and fluid retention associated
with heart failure. Indapamide may interact
with nutrients and herbs in ways similar to interactions described for thiazide diuretics, such as hydrochlorothiazide.
However, research has not investigated these interactions specifically for indapamide.
Summary of
Interactions with Vitamins, Herbs, and Foods
In some cases, an herb or supplement may appear in more than one category, which may seem
contradictory. For clarification, read the full article for details about the summarized
interactions.
 May Be Beneficial: Depletion or
interference—The medication may deplete or interfere with the absorption or
function of the nutrient. Taking these nutrients may help replenish them. |
Calcium
Lithium
Potassium
Sodium
Vitamin D*
|
| Side effect reduction/prevention |
None known
|
| Supportive interaction |
None known
|
| Reduced drug
absorption/bioavailability |
None known
|
| Adverse interaction |
None known
|
An asterisk (*) next to an item in the summary indicates that the
interaction is supported only by weak, fragmentary, and/or contradictory scientific
evidence.
Interactions with Dietary Supplements
Potassium and
Sodium
Taking indapamide may result in sodium and potassium loss, which may cause dry mouth, thirst,
fatigue, drowsiness, or muscle cramps.1 Doctors may suggest supplements or foods
high in potassium to prevent unwanted side effects.
Calcium
Slight increases in blood calcium levels may occur in people taking indapamide, which could be
aggravated by calcium supplementation.2 Therefore, people taking both calcium
supplements and indapamide should have their blood calcium levels monitored by their
healthcare practitioner, and it may be necessary to avoid calcium supplementation.
Lithium
Lithium is a mineral that may be present in some supplements and is also used in large amounts
to treat mood disorders such as manic-depression. Taking indapamide may elevate blood levels
of lithium, resulting in unwanted side effects such as diarrhea, nausea, and drowsiness.3 It is
unknown whether people taking small amounts of supplemental lithium will experience adverse
reactions.
Vitamin
D
Thiazide diuretics enhance the actions of
vitamin D;4 however, it is unknown whether indapamide has the same effect. Until
more is known, people taking indapamide should supplement vitamin D only under the supervision
of a health practitioner.
References:1. Sifton DW, ed. Physicians Desk Reference. Montvale, NJ:
Medical Economics Company, Inc., 2000, 1969–71.
2. Threlkeld DS, ed. Diuretics and Cardiovasculars, Diuretics, Thiazides
and Related Diuretics. In Facts and Comparisons Drug Information. St. Louis, MO:
Facts and Comparisons, 1999, 704–16.
3. Sifton DW, ed. Physicians Desk Reference. Montvale, NJ:
Medical Economics Company, Inc., 2000, 1969–71.
4. Threlkeld DS, ed. Diuretics and Cardiovasculars, Diuretics, Thiazides
and Related Diuretics. In Facts and Comparisons Drug Information. St. Louis, MO:
Facts and Comparisons, 1999, 704–16.