Also indexed as: Apresoline
Hydralazine is a drug used to lower blood pressure in people with hypertension. Hydralazine relaxes the muscles that
control the diameter of blood vessels. This relaxation allows the blood vessels to dilate
(open wider), lowering blood pressure.
Interactions with Vitamins, Herbs, and Foods
In some cases, an herb or supplement may appear in more than one category, which may seem
contradictory. For clarification, read the full article for details about the summarized
| May Be Beneficial: Depletion or
interference—The medication may deplete or interfere with the absorption or
function of the nutrient. Taking these nutrients may help replenish them.
|Side effect reduction/prevention
An asterisk (*) next to an item in the summary indicates that the
interaction is supported only by weak, fragmentary, and/or contradictory scientific
Interactions with Dietary Supplements
Vitamin B6 can bind to hydralazine to form a complex that is excreted in the urine, increasing
vitamin B6 loss.1 This may lead to vitamin B6 deficiency.2 People taking
hydralazine should consult with their doctor to discuss the possibility of vitamin B6
Interactions with Foods and Other Compounds
Taking hydralazine with food improves the absorption of the drug.3 People with
questions should ask their prescribing doctor or pharmacist.
Alcohol causes blood vessels to dilate, lowering blood pressure. This action may add to the
blood pressure-lowering effect of hydralazine and increase the risk of dizziness, fainting, or
accidental falls. People taking hydralazine should avoid alcohol and should read all product
labels carefully for alcohol content.
1. Holt GA. Food & Drug Interactions. Chicago: Precept
Press, 1998, 131–2.
2. Raskin NH, Rishman RA. Pyridoxine-deficiency neuropathy due to
hydralazine. N Engl J Med 1965;273:1182–5.
3. Threlkeld DS, ed. Diuretics and Cardiovasculars, Antihypertensives,
Vasodilators, Hydralazine. In Facts and Comparisons Drug Information. St. Louis, MO:
Facts and Comparisons, Dec 1993, 163r–4b.