Also indexed as: Atromid-S
Clofibrate is a drug used to lower
cholesterol in people with high blood cholesterol. It is rarely used, due to the
possibility of liver damage and the availability of safer, more effective drugs.
Summary of
Interactions with Vitamins, Herbs, and Foods
In some cases, an herb or supplement may appear in more than one category, which may seem
contradictory. For clarification, read the full article for details about the summarized
interactions.
 May Be Beneficial: Depletion or
interference—The medication may deplete or interfere with the absorption or
function of the nutrient. Taking these nutrients may help replenish them. |
Vitamin B12*
|
| May Be Beneficial: Side effect
reduction/prevention—Taking these supplements may help reduce the likelihood and/or
severity of a potential side effect caused by the medication. |
Milk thistle*
|
| Supportive interaction |
None known
|
| Reduced drug
absorption/bioavailability |
None known
|
| Adverse interaction |
None known
|
An asterisk (*) next to an item in the summary indicates that the
interaction is supported only by weak, fragmentary, and/or contradictory scientific
evidence.
Interactions with Dietary Supplements
Vitamin
B12
Clofibrate has been reported to reduce absorption of vitamin B12.1
Interactions with Herbs
Milk
thistle (Silibum marianum)
Although there have been no clinical studies, use of milk thistle with clofibrate may
theoretically lower the risk of liver side effects associated with the drug. People may take a
standardized milk thistle extract supplying 70–80% silymarin at an amount of 200 mg
three times per day.
References:1. Robinson C, Weigly E. Basic Nutrition and Diet Therapy. New
York: Macmillan, 1984, 46–54.