This drug is a combination of two active ingredients, benzoyl peroxide and erythromycin, which are applied topically to treat
mild to moderate acne. Benzoyl peroxide breaks
down and removes the outer layer of skin and exerts antibacterial activity. Erythromycin is
used as an antibacterial agent.
Interactions with Vitamins, Herbs, and Foods
In some cases, an herb or supplement may appear in more than one category, which may seem
contradictory. For clarification, read the full article for details about the summarized
| May Be Beneficial: Side effect
reduction/prevention—Taking these supplements may help reduce the likelihood and/or
severity of a potential side effect caused by the medication.
| May Be Beneficial: Supportive
interaction—Taking these supplements may support or otherwise help your medication
|Depletion or interference
An asterisk (*) next to an item in the summary indicates that the
interaction is supported only by weak, fragmentary, and/or contradictory scientific
Interactions with Dietary Supplements
Animal studies show that benzoyl peroxide promotes tumor growth, yet the significance of this
finding in humans is unknown. A test tube study showed that when exposed to vitamin E, human
skin cells were more resistant to damage caused by benzoyl peroxide.1 Controlled
research is needed to determine whether use of benzoyl peroxide products by humans promotes
tumor growth and whether vitamin E might prevent this damage.
Using a topical zinc solution with topical erythromycin increases the effectiveness of the
antibiotic in the treatment of inflammatory
1. Babich H, Zucherbraun HL, Wurzburger BJ, et al. Benzoyl peroxide
cytotoxicity evaluated in vitro with human keratinocyte cell line, RHEK-1. Toxicology
2. Toyoda M, Morohashi M. An overview of topical antibiotics for acne
treatment. Dermatology 1998;196:130–4.